This is the most amazing part that I have discovered in my work with Dr. David Phillips. The common link in all of these peripheral neuropathies, regardless of the cause, appears to be hypoxia.
Hypoxia is simply a word that describes loss of oxygen. This occurs at what are called the neuronal junctions. That is, the areas in the human body where one nerve cell communicates to another.
At a simplistic level, nerve cells communicate electrochemically across a gap. In neuropathy caused by hypoxia, this neuronal gap widens, which is theorized to be responsible for the symptoms that include not only the burning and the tingling but the shooting pains as well.
With permission here is some information from David Phillps, PhD:
Neuropathy and chronic pain: The Condition
By David Phillps, PhD
Neuropathy and chronic pain is characterized by pain, numbness, loss of tactile feedback, and poor tissue perfusion. These symptoms may indicate that oxygen is not getting to all the cells causing dysfunction.
Because the patient’s quality of life is decreased, these results are often devastating. Pain medications do not cure the condition; it only helps mask it and, eventually, leads to complications with adverse side effects such as mental confusion and intestinal problems. As a result of conducting our own research and reviewing published studies from around the world, we have been led to new models concerning the causes of neuropathy and chronic pain. We have concluded that it is not reasonable to merely label neuropathy and chronic pain symptoms as diabetic, peripheral, vascular, or “idiopathic”. What is needed is a more full understanding of the etiology of the condition so new technology can be brought to bear with both ameliorative and therapeutic benefits.